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A New Era in Gene Editing, by Caroline Petersen – Brown Pelican Society of Lousiana

A New Era in Gene Editing, by Caroline Petersen

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Sangharsh Lohakare. Unsplash. Genes, DNA

By Caroline Petersen, The American Spectator, June 9, 2026,

Caroline Peterson is an editorial intern at The American Spectator.

 

A recent paper promises greater accuracy in gene editing, while ethical considerations of human engineering remain.

A new scientific paper published last week by Dr. Dieter Egli and his genetics research team at Columbia University examines a new gene editing technique that could eventually replace earlier CRISPR-based technologies. The new technique, known as base editing, allows researchers to change a person’s genetic code. As the paper explains, base editing is a process that involves purposely creating nicks and mismatches in a “defective” gene sequence, and then repairing these sequences “in human embryos, allowing specific on-target changes without genotoxic consequences.”

Base editing is promoted by Dr. Egli as a safer alternative to other gene-editing technologies. Many people are familiar with the groundbreaking 2012 invention of CRISPR, one of the original gene-editing techniques. According to the Innovative Genetics Institute, CRISPR works by using a protein called Cas9 as a pair of metaphorical “molecular scissors to cut DNA.” And “when DNA is cut, it creates an opportunity to change the DNA sequence at and around the cut site by harnessing the cell’s natural pathways.” CRISPR was later approved for use in treating certain hereditary diseases. However, scientists have always recognized the risks involved in the technology, whether it be cutting out the wrong gene sequence or other harmful side effects. …

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